X-linked disorders are genetic conditions caused by mutations on the X chromosome and are almost always expressed in males.

X-linked disorders are genetic conditions caused by mutations on the X chromosome and are almost always expressed in males.

• A. X-linked disorders
• B. Autosomal recessive disease
• C. Autosomal dominant disease
• D. Mitochondrial inheritance

Answer: (A)

X-linked inheritance explains why these disorders are seen mostly in males. Males have only one X chromosome, so a single mutation on that X is enough to express the condition. Females have two X chromosomes, so a normal copy on the second X can often mask the defect, making them carriers rather than affected. This creates the typical pattern where males are affected more frequently, while autosomal or mitochondrial patterns would not produce that same male-biased expression. So the best match is X-linked disorders.

X-linked inheritance explains why these disorders are seen mostly in males. Males have only one X chromosome, so a single mutation on that X is enough to express the condition. Females have two X chromosomes, so a normal copy on the second X can often mask the defect, making them carriers rather than affected. This creates the typical pattern where males are affected more frequently, while autosomal or mitochondrial patterns would not produce that same male-biased expression. So the best match is X-linked disorders.